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JAB-3312

Reference Materials
Item No.CFZ07709
CAS Number:2245082-05-5
Purity:98%
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Basic information and product description
CAS number
2245082-05-5
Item number
CFZ07709
Chinese name
JAB-3312
English name
JAB-3312
Chinese alias
Spiro[6H-cyclopenta[b]pyridine-6,4'-piperidin]-5-amine, 1'-[5-[(2-amino-3-chloro-4-pyridinyl)thio]-2-pyrazinyl]-5,7-dihydro-, (5S)-
English alias
Spiro[6H-cyclopenta[b]pyridine-6,4'-piperidin]-5-amine, 1'-[5-[(2-amino-3-chloro-4-pyridinyl)thio]-2-pyrazinyl]-5,7-dihydro-, (5S)-
SMILES
Chemical name
Molecular formula
C₂₁H₂₂ClN₇S
Molecular weight
439.96
Purity
98%
Delivery
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Product Description

Sitneprotafib (JAB-3312) 是一种口服有效的致癌磷酸酶 SHP2 抑制剂 (IC50: 1.9 nM)，具有抗癌活性。Sitneprotafib 具有良好的耐受性，并在 KYSE-520 小鼠异种移植模型中显著引起肿瘤消退。 

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