KT-474

Item No.CFZ01423

CAS Number:2432994-31-3

Purity:98%

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PRODUCT CLASSIFICATION

News

NEWS

Application of bioactive small molecules in disease research

Green intelligence creates industry trends, Fuzhen Biology promotes low-carbon development of fine chemical industry

The monoclonal antibody industry is developing rapidly, and Fuzhen Biotechnology is improving its supply system for monoclonal antibody related raw materials

The global biopharmaceutical market continues to expand

Molecular building blocks are used as accelerators for the development of new drugs

Basic information and product description

CAS number

2432994-31-3

Item number

CFZ01423

Chinese name

KT-474

English name

KT-474

Chinese alias

5-((1R,4R)-2-氧杂-5-氮杂双环[2.2.1]庚烷-5-基)-N-(3-(二氟甲基)-1-(反式-4-((4-((3-(1-(2,6-二氧代哌啶-3-基)-3-甲基-2-氧代-2,3-二氢-1H-苯并[d]咪唑-4-基)丙-2-炔-1-基)氧基)哌啶-1-基)甲基）环己基)-1H-吡唑-4-基)吡唑并[1,5-a]嘧啶-3-甲酰胺

English alias

5-((1R,4R)-2-Oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(3-(difluoromethyl)-1-((1r,4R)-4-((4-((3-(1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)prop-2-yn-1-yl)oxy)piperidin-1-yl)methyl)cyclohexyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

SMILES

Chemical name

Molecular formula

C₄₄H₄₉F₂N₁₁O₆

Molecular weight

865.93

Purity

98%

Delivery

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Product Description

KT-474 (KYM-001; PROTAC IRAK4 degrader-7) 是一种具有口服活性的 PROTAC IRAK4 降解剂，具有抗肿瘤效果。KT-474 抑制细胞周期并诱导了细胞凋亡 (apoptosis)。KT-474 在 MYD88-突变 ABC DLBCL 的异种移植模型中诱导肿瘤消退。

Technical data and support

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KT-474

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