A-1331852

Item No.CFZ01373

CAS Number:1338934-59-0

Purity:98%

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PRODUCT CLASSIFICATION

News

NEWS

Application of bioactive small molecules in disease research

Green intelligence creates industry trends, Fuzhen Biology promotes low-carbon development of fine chemical industry

The monoclonal antibody industry is developing rapidly, and Fuzhen Biotechnology is improving its supply system for monoclonal antibody related raw materials

The global biopharmaceutical market continues to expand

Molecular building blocks are used as accelerators for the development of new drugs

Basic information and product description

CAS number

1338934-59-0

Item number

CFZ01373

Chinese name

MKC8866

English name

A-1331852

Chinese alias

7-羟基-6-甲氧基-4-甲基-3-(2-吗啉-2-氧乙基)-2-氧代-2H-苯并吡喃-8-醛

English alias

7-Hydroxy-6-methoxy-4-methyl-3-(2-morpholino-2-oxoethyl)-2-oxo-2H-chromene-8-carbaldehyde

SMILES

Chemical name

Molecular formula

C18H19NO7

Molecular weight

361.35

Purity

98%

Delivery

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Product Description

MKC8866 是一种水杨醛类似物，有效的选择性 IRE1 RNase 抑制剂，在体外的 IC50 为 0.29 μM。 MKC8866 强烈抑制 Dithiothreitol 诱导的 XBP1s 表达，EC50 为 0.52 μM。MKC8866 抑制无应激 RPMI 8226 细胞，IC50 为 0.14 μM。 MKC8866 抑制乳腺癌细胞中的 IRE1 RNase 导致促肿瘤发生因子减少，同时也能抑制前列腺癌 (PCa) 肿瘤的生长。

Technical data and support

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A-1331852

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