Monomethyl lithospermate B

Magnesium lithospermate B can protecte cardiomyocytes from ischemic injury through specific inhibition of TAB1-p38 apoptosis signaling. Magnesium lithospermate B is an inhibitor of lipid peroxidation and scavenge superoxide anions and hydroxyl radicals both in vitro and ex vivo. Magnesium lithospermate B can ameliorate cisplatin-induced injury in cultured renal epithelial cells.Magnesium lithospermate B is a naturally occurring, new generation antioxidant that activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress. Magnesium lithospermate B possesses inhibitory activity on Na+,K+-ATPase, it provides anti-ischemic neuroprotection in gerbilssubjected to focal ischemia and reperfusion. Magnesium lithospermate B has protective effects against diabetic atherosclerosis via Nrf2-ARE-NQO1 transcriptional pathway.Magnesium lithospermate B has potent antifibrotic effect in intraperitoneal thioacetamide (TAA)-treated cirrhotic rats, and inhibits fibrogenic responses in hepatic stellate cells (HSCs). Magnesium lithospermate B has depressor action on blood pressure in spontaneously hypertensive rats. Magnesium lithospermate B may stimulate the synthesis of kallikrein and/or conversion to active kallikrein, thus improving renal function. 10.Magnesium lithospermate B has anti-wrinkle and anti-aging effects on skin.