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Epibrassinolide is a biologically active compound of the brassinosteroids that can be isolated from various plants. It belongs steroid-derived plant growth regulator family and has been shown to decrease toxicity and stimulate healthy plant growth in plants under stress. It may be a potential apoptotic inducer in various cancer cells without affecting the non-tumor cell growth. It has also been shown to protect neuronal PC12 cells from 1-methyl-4-phenylpyridinium-induced oxidative stress and consequent apoptosis in dopaminergic neurons. It induced the decrease of intracellular polyamine levels accompanied by a significant ornithine decarboxylase (ODC) down-regulation in each prostate cancer cell.
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