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Chrysoeriol is a natural compound isolated from the herbs of Medicago sativa. Chrysoeriol can potently inhibit the induction of nitric oxide synthase by blocking activator protein 1 (AP-1) activation and its anti-inflammatory effects. Chrysoeriol can induce nod genes in rhizobium meliloti. Chrysoeriol can inhibit the downstream signal transduction pathways of platelet-derived growth factor (PDGF)-Rbeta, including ERK1/2, p38, and Akt phosphorylation, which suggests that chrysoeriol may be used for the prevention and treatment of vascular diseases during restenosis after coronary angioplasty.
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