Withaferin A

Item No.CFZ08366

CAS Number:5119-48-2

Purity:98%

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PRODUCT CLASSIFICATION

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Basic information and product description

CAS number

5119-48-2

Item number

CFZ08366

Chinese name

醉茄素 A

English name

Withaferin A

Chinese alias

English alias

NSC 101088; NSC-101088; NSC101088; NSC 273757; NSC-273757; NSC273757;

SMILES

CC1=C(C(=O)OC(C1)C(C)C2CCC3C2(CCC4C3CC5C6(C4(C(=O)C=CC6O)C)O5)C)CO

Chemical name

Molecular formula

C27H36O7

Molecular weight

472.57

Purity

98%

Delivery

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Product Description

Withaferin A used as an important medicinal herb for over 3000 years, is a steroidal lactone derived from Acnistus arborescens, Withania somnifera and other members of Solanaceae family. This natural product has wide range of pharmacological application comprising of anti-obesity, anti-inflammatory, anti-neoplastic, antiangiogenic, etc. WITHAFERIN A inhibits endothelial cells (HUVEC) sprouting (in vitro: IC50 = 12 nM and in vivo), activation of IKKβ (IC50= 0.5-1 μM), chymotrypsin-like activity of the 20S proteasome and cell proliferation of uveal melanoma cells (IC50= 0.90, 1.66, and 2.42 μM for OMM2.3, 92.1, and MEL290 cells, respectively).

Technical data and support

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Withaferin A

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