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Negletein has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells.Negletein shows a comparable redox-active potential, and it (50 μM, 4 h) can activate Nrf2. Negletein shows significant antimicrobial activity. Negletein has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.
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