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Sarsasapogenin, that can be found in the rhizomes of Anemarrhena asphodeloides Bunge, exhibited antitumor activity by inducing apoptosis in vitro as determined by Hoechst staining analysis and double staining of Annexin V-FITC/PI. Most of the Sarsasapogenin derivatives displayed excellent selective cytotoxicity toward the cancer cell lines.
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