Ailanthone

Item No.CFZ07913

CAS Number:981-15-7

Purity:98%

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PRODUCT CLASSIFICATION

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NEWS

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Basic information and product description

CAS number

981-15-7

Item number

CFZ07913

Chinese name

臭椿酮

English name

Ailanthone

Chinese alias

臭椿苦酮;

English alias

Ailantone;

SMILES

CC1=CC(=O)C(C2(C1CC3C45C2C(C(C(=C)C4CC(=O)O3)O)(OC5)O)C)O

Chemical name

Molecular formula

C20H24O7

Molecular weight

376.41

Purity

98%

Delivery

惯例下常温包邮

Product Description

Ailanthone (AIL, Δ13-Dehydrochaparrinone), a natural anti-hepatocellular carcinoma (HCC) component in Ailanthus altissima, induces G0/G1-phase cell cycle arrest by decreasing expression of cyclins and CDKs and increases expression of p21 and p27. Ailanthone triggers DNA damage characterized by activation of the ATM/ATR pathway. Ailanthone induces apoptosis which is mitochondrion-mediated and involves the PI3K/AKT signaling pathway in Huh7 cells. Ailanthone is also a potent inhibitor of both full-length Androgen Receptor (AR-FL) and constitutively active truncated AR splice variants (AR-Vs, AR1-651) with IC50 of 69 nM and 309 nM, respectively.

Technical data and support

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Ailanthone

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