PRODUCT CLASSIFICATION
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21-Deoxycortisone is a corticosteroid metabolite of 11-keto progesterone. It is formed from 11-keto progesterone by the cytochrome P450 (CYP) isoform CYP17A1, but can also be produced via oxidation of 21-deoxycortisol by 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). Levels of 21-deoxycortisone are increased in patients with congenital adrenal hyperplasia, an inborn error of metabolism characterized by a deficiency in 21-hydroxylase.
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