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Podofilox is a potent inhibitor of microtubule assembly and DNA topoisomerase II. It is a kind of non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum plant and has shown to inhibit the growth of various carcinoma cells. Podophyllotoxin is a natural product that inhibits the polymerization of tubulin and has served as a prototype for the development of diverse antitumor agents in clinical use.
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