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GDC-6036

Reference Materials
Item No.CFZ01321
CAS Number:2417987-45-0
Purity:98%
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Basic information and product description
CAS number
2417987-45-0
Item number
CFZ01321
Chinese name
GDC-6036
English name
GDC-6036
Chinese alias
1-((S)-4-(7-((R)-6-氨基-4-甲基-3-(三氟甲基)吡啶-2-基)-6-氯-8-氟-2-(((S)-1-甲基吡咯烷-2-基)甲氧基)喹唑啉-4-基)-3-甲基哌嗪-1-基)丙-2-烯-1-酮
English alias
1-((S)-4-(7-((R)-6-Amino-4-methyl-3-(trifluoromethyl)pyridin-2-yl)-6-chloro-8-fluoro-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)quinazolin-4-yl)-3-methylpiperazin-1-yl)prop-2-en-1-one
SMILES
Chemical name
Molecular formula
C₂₉H₃₂ClF₄N₇O₂
Molecular weight
622.06
Purity
98%
Delivery
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Product Description

GDC-6036(化合物17a)是一种有效的K-Ras G12C抑制剂,IC50小于0.01μM。GDC-6036在K-Ras G12C烷基化HCC1171细胞中的EC50为2 nM[1]。 

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