Onjisaponin B is extracted from the roots of Polygala tenuifolia. It was able to induce autophagy and accelerate both the removal of mutant huntingtin and A53T α-synuclein, which are highly associated with Huntington disease and Parkinson disease, respectively. It induces autophagy via the AMPK-mTOR signaling pathway. It increased the NGF level and may have potential therapeutic effects for the treatment of Alzheimer disease patients.
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