Monocrotaline is a natural ligand that exhibits dose-dependent cytotoxicity as a pyrrolizidine alkaloid and toxic plant constituent; the alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. However, it also has therapeutic potential against hepatocellular carcinoma. It acts against p53, HGF and TREM1 proteins, which play a threatening role in causing hepatocellular carcinoma. It is a novel scaffold for liver cancer with superior efficacy and lesser side effects.
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