Neohesperidin dihydrochalcone is a semisynthetic glycoside chalcone, an artificial sweetener, and a derivative of neohesperidin. NHDC inhibits decreases in hepatic GSH levels and increases in serum aspartate aminotransferase (AST) and alanine transaminase (ALT) activity and hepatic levels of reactive oxygen species (ROS), thiobarbituric acid reactive substances (TBARS), NF-κB, IL-6, IL-1β, and TNF-α in a mouse model of acute liver injury induced by paraquat.
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