Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 uM. Irisolidone possesses high α-amylase inhibitory activity.Irisolidone may attenuate ethanol-induced gastritis by inhibiting the infiltration of immune cells, particularly neutrophils, through the regulation of CXCL-4 or IL-8 secretion.Irisolidone has anti-inflammatory activity, it may inhibit inflammatory reactions via NF-κB pathway. Irisolidone shows inhibitory activity on nitric oxide production from lipopolysaccharide-activated primary rat microglia. Irisolidone shows antiproliferative activity against amelanotic melanoma cells.
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