Dehydrodiconiferyl alcohol is purified from the stems of Cucurbita moschata. (+)-(2S,3R)-Dehydrodiconiferyl alcohol is an antioxidant, and has an inhibitory effect on VCAM-1 expression via JNK pathway in endothelial cells and therefore may serve as a novel pharmacological agent to improve endothelial dysfunction. Dehydrodiconiferyl alcohol also shows anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts.
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